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Key discussion points include: Primary indication : GLP-1 receptor agonists are prescribed for type 2 diabetes management (NICE NG28) or, in specific circumstances, weight management (NICE TA875 for semaglutide 2.4mg
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In line with this theory, increasing skeletal muscle carnitine availability has been reported to delay fatigue development by 25% in rat soleus muscle strips in vitro (Brass (1993)). Further more it is worth reiterating that the Stephens Group has demonstrated in the study involving intravenous L-carnitine administration that a 15% increase in skeletal muscle carnitine content, achieved during hyperinsulinemia, resulted in a 30% decrease in muscle PDC activity and 40% decrease in muscle lactate content compared with control
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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