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In addition to these three dehydrogenases, TPP is a required co-factor for the transketolase catalyzed reactions of the pentose phosphate pathway and it is required for the catabolism of the methyl-substituted fatty acid (phytanic acid) at the 2-hydroxyphytanoyl-CoA lyase reaction

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However, their bioavailability within physiological systems demands extensive pharmacokinetic studies to determine peptide concentrations in vivo that can exert a beneficial effect on wound healing in vitro

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