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Kim HJ, Lee JS, Cho WJ et al: Efficacy and safety of augmentation ileocystoplasty combined with supratrigonal cystectomy for the treatment of refractory bladder pain syndrome/interstitial cystitis with hunner's lesion

These trials involved thousands of people, giving researchers a clear picture of how common diarrhea and other side effects are

The bottom line GLP-1 drugs are not a replacement for insulin, and they are not officially approved for T1D (outside of the new 2026 ADA recommendation for T1D with obesity)

Dosing is titrated to achieve optimal IGF1 and cortisol patterns without dependency or adverse effects

Seek urgent medical help for new, severe, or worsening chest pain, fainting, severe shortness of breath, or symptoms that feel unusual for you