The decision should be based on comprehensive cardiovascular risk assessment, not just LDL cholesterol in isolation
It is also FDA approved for moderate to severe obstructive sleep apnea in adults with obesity
TREM-2 is expressed in lipid-associated macrophages that drive pathologies such as atherosclerosis, obesity, metabolic dysfunction-associated steatotic liver disease, myocardial remodeling, and fibrosis 6971
Protocol overview: Tirzepatide is administered once weekly with standard titration starting at 2.5mg
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The overall AE profilepredominantly gastrointestinal symptomswas comparable to that reported in previous randomized and observational studies