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discussion 2086-7

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522 These findings suggest that islet autoantibodies are not pathogenic in type 1 diabetes but rather a consequence of the immune-mediated destruction of -cells

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15 and Supplementary Data 1)

However, a puzzling aspect of S 0 biology is the low intracellular concentration of persulfides and polysulfides (low micromolar range) 15 relative to glutathione (millimolar range), which makes it difficult to rationalize an efficient scavenging role for S 0 species