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People who should be cautious Potent medications demand extra care in certain bodies. Common red flags: History of medullary thyroid carcinoma or MEN2 Prior pancreatitis or unexplained severe abdominal pain Significant kidney or liver impairment Severe GI motility disorders Advanced frailty with multiple interacting medications In these situations, the riskbenefit equation can flip, so decisions around tirzepatide should be made with a clinician who understands both the drugs nuances and the patients longterm longevity goals. How Long Should You Stay on Tirzepatide for Healthspan

doi:10.1016/j.dnarep.2017.06.020

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