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doi: 10.1016/j.cell.2016.06.001 19 CarabottiM.SciroccoA.MaselliM

39 As shown in the LEADER study (NCT01179048), the secondary composite outcome of persistent doubling of the serum creatinine level, new-onset persistent macroalbuminuria, end-stage renal disease or death due to renal disease occurred significantly less frequently in the treatment group than in the placebo group, with a hazard ratio of 0.78

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[DOI] [Google Scholar] 57.Ryan L., Prescott S.L

Favorece la circulacin: Su uso en sesiones de drenaje linftico mejora la circulacin y reduce la retencin de lquidos.

The possible reason is that in vivo rapid metabolism of gastrodin into 4-hydroxybenzyl alcohol (4-HBA) may reduce its application in vivo because 4-HBA exhibits limited biological activity ( in vivo stability of gastrodin may be a critical issue to solve for future applications