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We began exploring the efficacy of senolytics in tauopathy mouse models to determine the impact of senescent cells on brain structure and function relevant to AD neuropathology (35)

WHO Collaborating Centre for Drug Statistics and Methodology

doi: 10.1182/blood.2021014493 22 GulecSAndersonGJCollinsJF

Potential Research Applications: IGF-1 receptor binding affinity and cellular signaling studies Cellular growth and differentiation pathway research Binding protein resistance and in vitro stability mechanism models Growth factor analog activity and structure-function investigations For laboratory research only

To test this possibility, we knocked out TBK1 in WT, FIP200 KO, and ATG9A KO cells (Fig 3c)

Diagnostics 2020;10:443