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Description

Studies showed that TGF- induces the expression of the de novo serine [phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1) and phosphoserine phosphatase (PSPH)] and glycine [serine hydroxymethyltransferase 2 (SHMT2)] synthesis pathways in human fibroblasts (225)

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Once in the interstitial space, their size and surface coatings prolong retention, sustaining contrast for up to 48 hours post-injection in rodent glioma models (137)

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Frontiers in Pharmacology , 12, 654125

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