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71 In addition, extra-mitochondrial localization of branched-chain -keto acid dehydrogenase (BCKDH), a rate-limiting enzyme in BCAAs metabolism, has been reported in type 2 diabetic rat model (OLETF)
SAM is additionally required for phosphatidylcholine synthesis, which is abundant in neuronal membranes and is crucial for synaptogenesis and neurite outgrowth ( Vitamin B12 is a cofactor for the enzyme methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a crucial step in fatty acid metabolism (73)
26,2 (2020): e3234
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This results in: Lighter and more even skin tone Reduction in dark spots and hyperpigmentation Enhanced skin texture and natural radiance Improved overall skin health Moreover, glutathione has detoxifying effects that promote liver function, immunity, and antioxidant defense, contributing to healthier skin from within