One gold-standard tool for this purpose is the DEXA body composition scan (DEXA stands for Dual-Energy X-ray Absorptiometry)
Oxidative stress and accelerated aging are the clearest targets, since glutathione is the front-line molecule that neutralizes free radicals before they damage mitochondria and DNA
Proton pump inhibitors (PPIs) like omeprazole raise stomach pH, which may lower absorption of pH-sensitive oral formulations
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B12 supplementation is well-tolerated and does not add adverse effects