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Caruso U, Cravotto E, Tisone G, and et al

3.1.3 Profound links between dysregulation of iron metabolism and I/R AKI Iron metabolic homeostasisgoverned by absorption, utilization, and recyclingis critical for suppressing ferroptosis: disruption of this balance elevates free iron, which accelerates ROS accumulation via the Fenton reaction and renders cells more susceptible to ferroptosis (45, 82)

In studies in mice, TMAO has been shown to cause atherosclerosis, the disease process that leads to cholesterol-clogged arteries

This inverse relationship is also supported by previous studies that have shown that replacement of dietary long-chain fatty acids with medium-chain fatty acids reduces triglyceride accumulation by 50% in the murine liver [65]

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Even people who technically eat enough B12-rich foods may struggle to absorb it properly