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The disruption mechanisms of oxidative stress include oxidative damage to cellular components (protein oxidation, lipid peroxidation, and DNA damage), activation of matrix metalloproteinases, cytoskeleton reorganization, modulation of tight junction proteins, and upregulation of inflammatory mediators [81, 86, 87]

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Tumor Biology 36:86718678 Li J, Wang H, Zheng Z, Luo L, Wang P, Liu K, Namani A, Jiang Z, Wang XJ, Tang X (2018) Mkp-1 cross-talks with Nrf2/Ho-1 pathway protecting against intestinal inflammation