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There are no awards for pushing through the pain

[DOI] [PubMed] [Google Scholar] Lee M

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Repeated injection at the same site: Repeatedly injecting into the same location causes cumulative local irritation, increasing sensitivity and the likelihood of lumps, redness, or prolonged discomfort at that site

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The melting point is sensitive to extremely large changes in pressure, but generally this sensitivity is orders of magnitude less than that for the boiling point, because the solid-liquid transition represents only a small change in volume