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228 In summary, despite the notable therapeutic benefits of GLP-1RAs and GLP-1/GIP dual receptor agonists in managing metabolic disorders, their safety profiles during pregnancy require a more comprehensive investigation

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BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a naturally occurring protein found in human gastric juice

It is important to note that with long-acting GLP-1 receptor agonists, the gastric-emptying effect may diminish over time (tachyphylaxis), though other beneficial effects persist