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This is Epithalons signature mechanism and the one most cited in longevity literature

doi: 10.1016/j.molmet.2015.07.008 34 CraneJ.McGowanB

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Unlike sermorelin, its action is stronger but shorter-lasting

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ADA Standards of Care 2025) recommend that patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD) (or high risk) should be on a GLP-1 RA with proven CV benefit (or an SGLT2 inhibitor) as part of their regimen, independent of A1c, because of the outcome benefits ( [9] ) ( [144] )