Are there long-term safety concerns with taking GLP-1 medications continuously
Hepatology 43, 173181 (2006)
For instance, increased cysteine availability in plasma is related to an enhanced risk of breast cancer, particularly oestrogen receptor-positive (ER + ) and/or progesterone receptor-positive (PR + ) cancer and in combination with low folate availability in plasma
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Conversely, discontinuation rates were increased to 28.1% (95% CI 27.7, 28.4) at 1 year and 43.6% (95% CI 43.2, 44.0) at 3 years when using a grace period of 60 days (ESM Table 4)
Risk of Bias Assessment Risk of bias was assessed for all included studies