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Sustained elevation of hepatic enzymes occurs in roughly 15% of patients at standard doses of 0.5 to 1 mg/kg/day, which is why the iPLEDGE program mandates liver function testing at baseline and at each monthly visit [2]
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12 Canonical GLP-1 receptor signaling involves coupling GLP-1R with Gs, a subtype of G subunit, but GLP-1R can also initiate diverse signaling patterns through non-Gs pathways
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