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The patient may remain at a dose that provides an appropriate balance of results, safety, and manageable side effects

The reverse, adding too little water, creates an overly concentrated solution with the same problem in the opposite direction

Water molecules collide with the peptide chain with greater force

Below are some possible reasons: The Dose Might Be Too Low The initial dose starts low on purpose to minimize side effects like nausea

Others may have a slower metabolism, requiring more time to see the same results

Long-term real-world data and direct head-to-head trials (e.g., ongoing SURMOUNT-5) are recommended for confirmation.