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Safety outcomes (adverse events) were synthesized descriptively because AE reporting was incomplete and not sufficiently consistent across trials to support quantitative synthesis

For individuals with BMI above 40 or 50, the difference between 20% and 28% weight loss can be the difference between still being classified as obese and reaching a healthy weight range

Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Torne CW, Ryan DH (2023) Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes