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TLR signaling molecules, like mitogen-activated protein kinases (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), play fundamental roles in TLR-mediated cell proliferation and survival via reducing apoptosis and increasing time for viral replication (Li et al., 2010

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As a result: Preclinical strategies are exploring selective reduction of glutathione in tumor cells to increase chemosensitivity

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