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Furthermore, a network meta-analysis examining the effects of GLP-1 RA therapy on body composition reported a greater reduction in lean body mass in the intervention group compared with placebo or active comparators (mean difference = 0.86 kg, 95%CI: 1.30, 0.42)

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So it would follow that an effective weight-loss drug like GLP-1s would have a benefit for obese patients with arthritis

For people with severe renal impairment (eGFR below 30 mL/min/1.73 m) or those on dialysis, the evidence base for most weight loss medications is limited, and many are either contraindicated or lack sufficient safety data

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Mol Cell Endocrinol 2009