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SURPASS 1, SURPASS 5, and SURPASS J-combo are placebo controlled, while others have active comparators: for example GLP-1RAs (dulaglutide and semaglutide), long-acting insulin analogues (glargine and degludec), or short-acting insulin analogue (lispro)

Use a fresh sterile syringe and needle for each dose

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You also have to worry about light and moisture