Some focused primarily on cardiovascular outcomes, such as CV death and worsening heart failure events, without exploring into patient-centred outcomes like quality of life or functional capacity.34 Others explored the effects of GLP-1RAs across various HFpEF phenotypes but lacked quantitative synthesis of data and did not assess the impact on specific functional or quality-of-life measures, certain articles focused on mechanistic aspects of GLP-1RAs in endothelial function without providing clinical outcome data or performing systematic reviews or meta-analyses.35,36 In contrast, our study addresses these gaps by providing a focused, quantitative synthesis of data specifically targeting the HFpEF population
Clinically, it is considered among the least concerning for long-term use
6,7 However, while lysine can be sourced by choosing the right foods, getting too much of it may also lead to stomach difficulties, including abdominal cramps and diarrhoea
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