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Tirzepatide also activates GIP receptors, making it a dual-receptor agonist - a distinction that clinical research suggests may contribute to somewhat greater average weight reduction in study populations

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Improved glucose metabolism

GLP-1 acts primarily on the hypothalamic arcuate nucleus (POMC/NPY neurons) to regulate energy homeostasis and metabolic set-pointit's the 'background thermostat' for caloric balance