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Data from the World Health Organization (WHO) shows that obesity has almost tripled globally since 1975, impacting over 650 million adults and 340 million children and adolescents in 2016

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When setting the parameters in the model, the key factors for consideration are the concentrations at the steady state (or pseudo-steady state if a formal steady state cannot be achieved in a reasonable time), their response to stimuli (at least qualitatively in which direction and approximately how fast do they change, if no data are available), and the reaction and transport fluxes