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Because Ipamorelin is highly selective, it doesn't significantly spill into cortisol or prolactin pathways the main side effect concern with older GH-releasing compounds

When you take a drug that activates PXR (many do), then it will produce a bunch of enzymes that can eliminate the drug quite effectively [6], which is probably why you wont notice the same effects from the same dosage

[PubMed] [Google Scholar] 160.Luetic K., Sucic M., Vlainic J., Halle Z.B., Strinic D., Vidovic T., Luetic F., Marusic M., Gulic S., Pavelic T.T., et al

Think of BPC-157 as building the roads and TB-500 as sending the construction crews

7 Another pilot study on intravenous BPC-157 in two healthy adults found it was well-tolerated with no adverse events