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Silencing the Insr gene in primary brain microvascular endothelial cells (BMECs) The sequences of the siRNA-Insr used were as follows: 5-GCACAGACCAUUUGAGAAATT-3 (sense) and 5-UUUCUCAAAUGGUCUGUGCTT-3 (antisense)

13 The current study differed in its design (open-label, nonrandomized, pilot trial), higher carnitine dosage (200 mg/kg/day increasing to 400 mg/kg/day), and use of multiple behavioral measures (ADOS, SCQ, PDDBI, AIM, ABC, CGIS)

Labeled peptides were combined, dried in a vacuum concentrator, and stored at -80 C

This can further lower GSH levels

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