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If the decision is made to continue topiramate despite persistent acidosis, alkali treatment should be considered

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135,191,192 While this seminal work focused mostly on DNA recognition and the mechanism of transcriptional regulation, these authors noted the presence of a potential metal binding motif, later shown to be critical for imparting metal selectivity ( vide infra )

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Furthermore, Dihexa decreased the activation of astrocytes and microglia, markedly reduced levels of the pro-inflammatory cytokines IL-1 and TNF- and increased the levels of the anti-inflammatory cytokine IL-10