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Dave CV, Kim SC, Goldfine AB, Glynn RJ, Tong A, Patorno E

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Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus

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DES(1-3) IGF-1 signals through the same IGF1R PI3K/AKT and MAPK/ERK axes as IGF-1 LR3 but, because it lacks the N-terminal extension that confers extended half-life in LR3, its circulating stability is more comparable to native IGF-1

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As estrogen declines, insulin resistance increases

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The 1st glutathione-interaction site should be frequently (although transiently) occupied by GSH at millimolar concentrations, whereas diverse non-glutathione disulfide substrates are far less abundant in vivo and should encounter the active site less frequently

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This infusion is delivered via ultrasound-assisted transdermal technology into the freshly laser-treated skin, where temporary micro-channels created by the laser energy allow far deeper infusion penetration than is possible on untreated skin

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