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The combination can precipitate severe hyperthermia, muscle rigidity, and even death, so clinicians will avoid MB in patients on serotonergic psychiatric medications (or will stop those medications well in advance of giving MB if its needed emergently)

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According to the Merck Manuals, bioavailability is the extent and rate within which an active drug enters systemic circulation after passing through the first-pass metabolism sites, namely, the intestinal wall and liver

Assessment of DNA Damage in Testes from Young Wistar Male Rat Treated with Monosodium Glutamate

PMID: 36121652

Scholz, J