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Its activity is dynamically modulated by phosphorylation and dephosphorylation, primarily mediated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively
This includes upregulation of antioxidant enzymes (superoxide dismutase, catalase) that protect against oxidative damage, enhancement of growth factor expression (TGF-, VEGF, PDGF) that supports tissue repair, and suppression of inflammatory gene expression that contributes to chronic skin degradation
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