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Several studies reported that the clinical severity of the disease in the EAE model was significantly downregulated by curcumin, which was able to reduce the mRNA expression of IL-17, transforming growth factor (TGF)-, IFN-, IL-6, IL-21, IL-23, signal transducer and activator of transcription (STAT)3, and retinoic-acid-receptor-related orphan nuclear receptor gamma (RORt) (Kanakasabai et al., 2012), to modulate the CD4 + T cells and toll-like receptors (TLRs) (Xie et al., 2009)

Mamane, Y., Petroulakis, E., LeBacquer, O

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