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According to general FDA guidelines, weight loss versions of these drugs (Wegovy and Zepbound) are approved for: Adults with a Body Mass Index (BMI) of 30 or higher (classified as obese)

2020;11 doi: 10.1038/s41467-020-18565-8.4765 [DOI] [PMC free article] [PubMed] [Google Scholar] 123.Li C., Zhang L., Qiu Z., Deng W., Wang W

Effects of a plant-based high-carbohydrate/high-fiber diet versus high-monounsaturated fat/low-carbohydrate diet on postprandial lipids in type 2 diabetic patients

Certainly, human patients with T2DM display a blunted incretin effect of GLP-1, and defects in meal-induced intestinal GLP-1 secretion (91), suggesting that the paracrine action of alpha-cell-derived GLP-1 may be necessary to combat this diminished peripheral incretin action of gut-derived GLP-1

This is a formidable problem for researchers

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