GLP-1 increased the expression of mRNA and transcription factors that play a part in the pleiotropic effects such as DNA synthesis in pancreatic beta cells, metabolic enzyme gene expression, and insulin biosynthesis
Rarely, more serious side effects like pancreatitis or vision-related conditions can occur
Asmar, C.M
But what was striking is the challenge, and this is one of the first important questions about, when you had the extended half-life of the first GLP-1 drug, that instead of having to take multiple times a day, you could actually, with liraglutide get to a point where you were starting to get to an extended half-life
(Ghrelin)
[97] observed a potential association between semaglutide and NAION, with incidence rates of 4.28 and 7.64 per 1,000 person-years in patients with T2DM and those who were overweight or obese, respectively, over 36 months