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Although creatine, synthesized by the kidneys and liver, can be transported from the blood into the brain, during both embryonic development and during postnatal life the brain can directly synthesize its own creatine

For example, by focusing on just three different modes of aging in yeast cells, researchers found that the complex interactions among multiple complex pathways could be modelled mathematically, providing a better understanding of these landscape patterns in aging and allowing them to drive certain gene expression patterns that could optimize cell lifespan (84)