Clinical trial status Eli Lilly is running seven Phase 3 clinical trials evaluating retatrutide for obesity, type 2 diabetes, and related metabolic conditions
GLP-1 receptor agonists for weight reduction in people living with obesity
Potential Benefits and Risks of Microdosing GLP-1 Microdosing GLP-1 is proposed to reduce dose-dependent gastrointestinal side effects such as nausea and vomiting, but lacks randomised controlled trial evidence for efficacy or safety
External resources New England Journal of Medicine - Retatrutide Phase 2 Trial Results PubMed Central - Retatrutide Systematic Review and Meta-Analysis For researchers serious about optimizing their peptide research protocols, SeekPeptides offers the most comprehensive resource available, with evidence-based guides, proven protocols, dosage calculators, and a community of thousands of researchers who have navigated these exact sourcing and quality questions
They copy a natural hormone in your body called GLP1, which is made in the gut after you eat
The Phase 2 trial published in the New England Journal of Medicine in 2023 confirmed this pharmacokinetic profile