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Each dose increase may trigger a recurrence of gastrointestinal symptoms, including diarrhea, though subsequent episodes are often less severe than initial symptoms

The cancelled 2015 Phase I trial (NCT02637284) was almost certainly abandoned for this reason rather than buried by a regulator

For optimal results, combine with a healthy lifestyle and consult with a healthcare provider before starting any new supplement regimen

Chelation therapy is FDA-approved for treating heavy metal poisoning

Obesity has also been seen to affect the quality of life and negatively impact mental health

10.1080/15548627.2017.1309485 56 KirklandJ