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While medication alone wont solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms. The WHO did qualify its recommendations, saying endorsement is conditional due to limited data on their long-term efficacy and safety, maintenance and discontinuation, their current costs, inadequate health-system preparedness, and potential equity implications. The drugs should not be used by pregnant women, and should be paired with evidence-based interventions like healthy diets and physical activity, the guidelines also stress

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12,17,6369 APAP protein adducts that form upon NAPQI conjugation with protein sulfhydryl groups of cysteine in GSH or cellular proteins readily interact with mitochondria

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It interacts with DNA to form adductssuch as DNADNA and DNAproteins crosslinkswhich activate several signal transduction pathways that trigger cell death 74,76