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Without regular support, reserves fall, leaving cells less protected.10-13

The HXR9 peptide (WYPWMKKHHRRRRRRRRR) interferes with the interactions between HOX and PBX in several mouse tumor models 139,142

The following shRNA constructs were used (See also Key Resources Table): shGFP, shFOXO4-1: TRCN0000039720, Mature sequence: CCAGCTTCAGTCAGCAGTTAT, shFOXO4-2: TRCN0000039721, Mature sequence: CGTCCACGAAGCAGTTCAAAT, shFOXO4(mouse): TRCN0000071560, Mature sequence: GATCTGGATCTTGATATGTAT, shp53-1: TRCN0000003753, Mature sequence: CGGCGCACAGAGGAAGAGAAT and shp53-2: TRCN0000003754, Mature sequence: TCAGACCTATGGAAACTACTT

Drug Dev Res (2009) 70:47280.10.1002/ddr.20328 9 WrightJWHardingJW

Anticancer Drugs 5 , 5675729 (1994)

10.1159/000355140 Eur