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All these aspects can be captured by metabolomics and especially in the context of IHD, which involve disturbances in cardiac metabolism 25,27,28 as a consequent of ischemia, leading to changes in substrate metabolism and contractile function

The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]

Tyrosinaemia type I and NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione)

Plumbagin exhibits genotoxicity and induces G2/M cell cycle arrest via ROS-Mediated oxidative stress and activation of ATM-p53 signaling pathway in hepatocellular cells

Marrades RM, Roca J, Barber JA et al (1997) Nebulized glutathione induces bronchoconstriction in patients with mild asthma