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We thank Christopher Koscher for his assistance with protein expression and purification and Florian Grebien for help with establishing the RPE-1 cell lines stably expressing p53 and p53 mutants

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In vitro, it upregulates extracellular matrix genes (COL1A1, elastin, decorin) while suppressing inflammatory cytokines

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However, aside from inhibiting nitric oxide synthesis, DPI has been demonstrated to possess antibacterial activity [83] and induce oxidative stress in murine glial cells [84]

This supports better embryo formation and overall reproductive health