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Int J Clin Pharmacol Res 1995;15:9-15

The net effect of the mismatch between increased ATP demand and decreased ATP generation is increased renal oxygen consumption, ultimately rendering the kidney susceptible to renal hypoxia [15]

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3,9,13 There is evidence to support the theory that the metabolic activation of APAP generates NAPQI that binds to a number of cellular proteins, especially mitochondrial proteins

The regulatory status factor An important consideration that affects the risk calculus: cagrilintide is not currently FDA-approved as a standalone medication

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