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J Diabetes Investig 7(suppl 1):15055
Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
Regulatory frameworks require detailed impurity profiling (0.10%) and stability-indicating assays, making LC-MS an essential tool in GLP-1 drug development and quality control
Diabetes Care 48 , S181S206 (2025)
While GLP-1 medications are meant for long-term use, this is not always feasible for every patient
cite How do GLP-1 oral drops work
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