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For instance, one study reported that although tirzepatide would avert 45 609 obesity cases (95% uncertainty interval (UI): 45 092 - 46 126) per 100 000 individuals and semaglutide would avert 32 087 cases (95% UI: 31 292 - 32 882) per 100 000 individuals, their respective incremental cost-effectiveness ratios in the United States were $197 023 per QALY and $467 676 per QALY in the US

Weight regain is common after discontinuing Zepbound, particularly if lifestyle modifications such as dietary changes and increased physical activity are not maintained

These results suggest that positive PGC-1-Mfn2 regulation and negative PGC-1-Drp1 regulation maintain the balance of mitochondrial dynamics

Nurses can provide education about lifestyle modifications, such as reducing caloric intake, increasing physical activity, and creating sustainable lifelong healthy habits to preventing rebound weight gain after discontinuing pharmacotherapy

doi: 10.3390/nu5020525

Citations: Centers for Disease Control and Prevention