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Previously, researchers have shown that GLP-1 mimics can alter the reward value associated with food, alcohol, cocaine, and nicotine

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1 Introduction Cardiovascular disease (CVD) continues to be a significant global health concern, with ischemic stroke and acute myocardial infarction ranking as the second and third leading causes of death worldwide in 2019 ( The complex interaction between diabetes mellitus (DM) and cardiovascular events complicates patient management

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In addition, personalized techniques that make use of gut microbiome profiling have the potential to guide the identification of people who are most likely to benefit from therapies of this kind [59]