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Circulating and locally produced IGF-1 mediates many of GHs downstream effects and also feeds back negatively on both the hypothalamus and pituitary to restrain further GH release

Whilst healthy hemoglobin reversibly rearranges during deoxygenation, sickle hemoglobin, on the other hand, forms helical structures (Kuypers, HbS polymerisation results in rigid, fragile sickle cells with up to a 75% reduction in lifespan (Kaul et al., Oxidative stress is both cause and effect of increased erythrocyte haemolysis (Kato et al., 2007)

The Kolonin mouse study that started everything In 2004, Mikhail Kolonin and colleagues published a landmark study in Nature Medicine titled "Reversal of obesity by targeted ablation of adipose tissue." This was the paper that introduced the world to vascular-targeted fat destruction

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