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Thereby preserving nicotinamide adenine dinucleotide (NAD+) pools in adipocytes

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Proactive dietary modifications can help counteract these changes and support weight maintenance without the pharmacological assistance previously provided

In particular, the cystine/glutamate antiporter (System X c ), glutathione peroxidase 4 (GPX4) and glutathione (GSH) (System X c /GSH/GPX4 axis) plays a key role in preventing lipid peroxidation-mediated ferroptosis, because of which could be inhibited by blocking System X c /GSH/GPX4 axis

Many studies have demonstrated that apigenin is non-toxic and non-mutagenic [132]