The employers also attributed other related and desirable outcomes to adding GLP-1s: Higher employee satisfaction/wellbeing (75%) Increased engagement in other wellbeing programs (58%) Improvement in other/comorbid health conditions (57%) Overall, the survey results indicate that cost is not the only reason employers are not providing coverage of GLP-1 medications
They propose based on rodent and monkey studies that this kind of molecule, when administered at high enough doses, may result in weight loss comparable to the weight loss seen with drugs that include GLP-1 as a target, and without the tolerability issues like nausea and vomiting that often come with the approved treatments, according to a peer-reviewed draft paper published this week
The narrative surrounding off-brand semaglutide and tirzepatide use is beginning to shift as tirzepatide was removed from the FDAs drug shortage list in December and semaglutide was taken off the list in February
Altered gut microbiota composition with antibiotic treatment impairs functional recovery after traumatic peripheral nerve crush injury in mice: Effects of probiotics with butyrate producing bacteria
According to FDA labeling, the common side effects include: Gastrointestinal effects (with frequencies varying by dose): Nausea (12-30% of patients, often most prominent during dose escalation) Diarrhea (7-22%) Vomiting (2-10%) Constipation (5-17%) Abdominal pain or discomfort (5-10%) Decreased appetite (5-10%) Dyspepsia/indigestion (2-9%) Gastroesophageal reflux disease (1-5%, more common in weight management indication) Eructation/belching (more common in weight management indication) These gastrointestinal symptoms typically occur early in treatment or following dose increases and often diminish over time as the body adjusts to the medication
"If a microdose is potent enough to alter your appetite, it is potent enough to alter your biology," says Dr