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Less frequent but more serious risks include pancreatitis, gallbladder issues, and in rare cases, thyroid tumors

The European Medicines Agency reviewed GLP-1 receptor agonists in 2024 and found no causal link between these medications and depression or suicidal thoughts, though monitoring continues

Both belong to a class of drugs known as incretin mimetics

Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis

These new studies show small relative NAION risk with GLP-1s mostly in T2D patients (RR ~1.7-2.5), but absolute risks are very low (~0.02-0.08% over years) and attenuated after diabetes adjustment, suggesting confounding more than causation